In the globalized business environment, communication is strongly influenced by cultural factors that shape expression styles, negotiation strategies, and hierarchical relationships within organizations. This paper explores the interaction between culture and business communication, emphasizing the importance of intercultural competencies in international business. Special attention is given to Hofstede’s cultural dimensions, which explain differences in communication patterns, perceptions of authority, decision-making processes, and approaches to risk across various cultures. The analysis of negotiation processes reveals that competitive and direct negotiation styles dominate in individualistic and low-context cultures, whereas collectivist and high-context cultures prefer long-term relationships and consensus-building. Language barriers, stereotypes, and cultural shock pose additional challenges in international business, complicating cross-cultural collaboration. This paper highlights how the development of intercultural competencies, adaptation of communication styles, and education on cultural differences can significantly improve business relationships and reduce misunderstandings. Organizations that invest in understanding and adapting to intercultural challenges achieve better business results and establish long-term partnerships in the global market.